Can You Take felodipine and grapefruit Together?
Evidence-based clinical pharmacological assessment, adverse synergy evaluation, and administration separation protocols.
Co-administering felodipine and grapefruit has documented pharmacodynamic or pharmacokinetic antagonism capable of triggering acute clinical harm. Do not combine without explicit specialist oversight.
Clinical Mechanism & Evidence Details
Suppression of aldosterone causes renal potassium retention; potassium salt substitutes can trigger sudden, life-threatening hyperkalemic cardiac arrest.
Alcohol may enhance gastrointestinal irritation, trigger orthostatic hypotension, or alter drug absorption kinetics.
Alcohol may enhance gastrointestinal irritation, trigger orthostatic hypotension, or alter drug absorption kinetics.
Talk to your doctor before using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.
Taking other supplements, foods, or medications with this pair?
Add your morning coffee, daily multivitamins, prescription pills, and dinner foods into our instant browser-based radar to check for multi-way chain reactions.
Clinical mechanism and interaction severity derived from openFDA Drug Structured Product Labeling (Section 7), NIH Office of Dietary Supplements (ODS), and NIH NCCIH clinical botanicals database.