Simeprevir

Comprehensive clinical interaction and dietary monograph for Simeprevir (Simeprevir).

Generic Active Chemical: Simeprevir

Brand Formulations:Olysio

Quick Jump:Kitchen Foods (1)Drug Red Flags (0)Supplements & Herbs (0)Administration Timing (1)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

1 Flagged Foods

HIGH

Dairy Milk, Yogurt & Calcium-Enriched Foods

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:Ionic Calcium (Ca2+) & Casein Micelles

Biological Target:Intestinal Chelation & Luminal Complexation

Clinical Mechanism:

Divalent calcium binds fluoroquinolone (ciprofloxacin) and tetracycline (doxycycline) antibiotics into unabsorbable ring complexes, reducing systemic antibacterial coverage by up to 90% and causing therapy failure.

Patient Actionable Rule:Separate all dairy ingestion from oral antibiotics, bisphosphonates, and thyroid medications by at least 2 to 4 hours.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

0 Warning Classes

No major contraindicated drug classes listed in the basic monograph. Always provide your complete medication list to your prescribing physician.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

0 Monitored

No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

1 Protocols

MEALMealtime Administration

It is usually taken with food once a day.

Rationale: Food enhances bioavailability, prevents gastric mucosal irritation, or stabilizes peak-to-trough pharmacokinetic variations.

Multi-Substance Interactive Radar

Taking Simeprevir alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Simeprevir→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers