Panobinostat

Comprehensive clinical interaction and dietary monograph for Panobinostat (Panobinostat).

Generic Active Chemical: Panobinostat

Brand Formulations:Farydak

Quick Jump:Kitchen Foods (1)Drug Red Flags (0)Supplements & Herbs (0)Administration Timing (0)Pairwise Combos (3)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

1 Flagged Foods

Official Patient Dietary Instruction (NLM MedlinePlus)

Do not eat pomegranate, grapefruit or star fruit or drink grapefruit or pomegranate juice while taking this medication.

CRITICAL

Grapefruit / Pomelo (Citrus paradisi / Citrus maxima)

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:Furanocoumarins (Bergamottin, 6',7'-Dihydroxybergamottin)

Biological Target:Intestinal Cytochrome P450 3A4 (CYP3A4) & P-glycoprotein

Clinical Mechanism:

Destroys enterocyte CYP3A4 enzymes, collapsing first-pass drug metabolism and causing up to 12-fold spikes in bioavailability for oral CYP3A4 substrates (statins, calcium channel blockers, immunosuppressants, PDE5 inhibitors).

Patient Actionable Rule:Completely avoid grapefruit, pomelos, and Seville oranges for the entire duration of therapy. Normal intestinal CYP3A4 enzyme turnover takes up to 72 hours to regenerate after ingestion.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

0 Warning Classes

No major contraindicated drug classes listed in the basic monograph. Always provide your complete medication list to your prescribing physician.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

0 Monitored

No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

0 Protocols

Frequently Researched Drug-Substance Combinations

Explore pairwise interaction dossiers and laboratory safety analyses

HIGH→

Multi-Substance Interactive Radar

Taking Panobinostat alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Panobinostat→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers