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Verified Evidence Sources: openFDA & NLM MedlinePlus

Oxycodone Combination Products

Comprehensive clinical interaction and dietary monograph for Oxycodone Combination Products (Oxycodone Combination Products).

Generic Active Chemical: Oxycodone Combination Products
Brand Formulations:Codoxy(as a combination product containing Ibuprofen, Oxycodone)¶Combunox(as a combination product containing Ibuprofen, Oxycodone)¶Oxycet(as a combination product containing Acetaminophen, Oxycodone)Percocet(as a combination product containing Acetaminophen, Oxycodone)Percodan(as a combination product containing Aspirin, Oxycodone)Roxicet(as a combination product containing Acetaminophen, Oxycodone)¶Roxilox(as a combination product containing Acetaminophen, Oxycodone¶Roxiprin (as a combination product containing Aspirin, Oxycodone)¶Targiniq (as a combination product containing Naloxone, Oxycodone)¶Troxyca ER (as a combination product containing Naltrexone, Oxycodone)¶Tylox(as a combination product containing Acetaminophen, Oxycodone)¶Xartemis XR (as a combination product containing Acetaminophen, Oxycodone)¶
Quick Jump:Kitchen Foods (3)Drug Red Flags (1)Supplements & Herbs (0)Administration Timing (0)Pairwise Combos (5)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients
3 Flagged Foods
Official Patient Dietary Instruction (NLM MedlinePlus)

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.

CRITICAL

Grapefruit / Pomelo (Citrus paradisi / Citrus maxima)

NutriDive Kitchen Food Biochemical Ontology & openFDA
Bioactive Compound:Furanocoumarins (Bergamottin, 6',7'-Dihydroxybergamottin)
Biological Target:Intestinal Cytochrome P450 3A4 (CYP3A4) & P-glycoprotein
Clinical Mechanism:

Destroys enterocyte CYP3A4 enzymes, collapsing first-pass drug metabolism and causing up to 12-fold spikes in bioavailability for oral CYP3A4 substrates (statins, calcium channel blockers, immunosuppressants, PDE5 inhibitors).

Patient Actionable Rule:Completely avoid grapefruit, pomelos, and Seville oranges for the entire duration of therapy. Normal intestinal CYP3A4 enzyme turnover takes up to 72 hours to regenerate after ingestion.
HIGH

Fresh Orange Juice & Apple Juice (OATP Influx Blockers)

NutriDive Kitchen Food Biochemical Ontology & openFDA
Bioactive Compound:Flavonoid Glycosides (Naringin, Hesperidin)
Biological Target:Organic Anion Transporting Polypeptides (OATP1A2 & OATP2B1)
Clinical Mechanism:

Unlike CYP3A4 inhibitors that increase drug levels, fruit juice bioflavonoids block the enterocyte OATP influx pumps, plummeting absorption of oral fexofenadine (Allegra), ciprofloxacin, and atenolol by 30-70%.

Patient Actionable Rule:Take fexofenadine (Allegra) and atenolol with plain water only. Avoid drinking fruit juices within 4 hours before or after dosage.
HIGH

Alcoholic Beverages (Beer, Wine, Spirits)

NutriDive Kitchen Food Biochemical Ontology & openFDA
Bioactive Compound:Ethanol
Biological Target:GABA-A Receptors, Hepatic CYP2E1 & Gluconeogenesis
Clinical Mechanism:

Multiplies respiratory depression and profound sedation with opioids and sedatives; blocks hepatic lactate uptake with metformin (lactic acidosis); triggers acute disulfiram-like vomiting and tachycardia with metronidazole; and accelerates dose-dumping in extended-release capsules.

Patient Actionable Rule:Completely abstain from alcohol while taking metronidazole, cephalosporins, prescription sedatives, or empty-stomach metformin.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions
1 Warning Classes
HIGH RISK

NSAIDs (Ibuprofen, Naproxen) & Non-Cardioprotective Analgesics

openFDA SPL Section 7 (Drug Interactions)

Mechanism: Inhibition of renal vasodilatory prostaglandins (PGI2, PGE2) causes afferent arteriolar vasoconstriction, blunts blood pressure control, and increases risk of acute kidney injury (AKI).

Clinical Consequence: Loss of blood pressure reduction, fluid retention, or acute renal hemodynamic compromise.
Physician Precaution: Consult your physician before taking OTC pain relievers. Acetaminophen may be preferred for occasional pain depending on liver status.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations
0 Monitored
No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols
0 Protocols

Frequently Researched Drug-Substance Combinations

Explore pairwise interaction dossiers and laboratory safety analyses
HIGH→

Oxycodone Combination Products and Grapefruit

Pairwise Clinical Analysis & Safety Rating
HIGH→

Oxycodone Combination Products and Grapefruit-juice

Pairwise Clinical Analysis & Safety Rating
CRITICAL→

Oxycodone Combination Products and Grapefruit / Pomelo

Pairwise Clinical Analysis & Safety Rating
HIGH→

Oxycodone Combination Products and Aspirin / NSAIDs

Pairwise Clinical Analysis & Safety Rating
HIGH→

Oxycodone Combination Products and Alcoholic Beverages

Pairwise Clinical Analysis & Safety Rating
Multi-Substance Interactive Radar

Taking Oxycodone Combination Products alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Oxycodone Combination Products→
Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers