Mesalamine

Comprehensive clinical interaction and dietary monograph for Mesalamine (Mesalamine).

Generic Active Chemical: Mesalamine

Brand Formulations:AprisoAsacol¶Asacol HDDelzicolLialdaPentasa

Quick Jump:Kitchen Foods (1)Drug Red Flags (1)Supplements & Herbs (0)Administration Timing (2)Pairwise Combos (1)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

1 Flagged Foods

HIGH

Aged Cheese, Cured Meats & Fermented Foods (High-Tyramine)

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:Tyramine (Decarboxylated Tyrosine)

Biological Target:Presynaptic Vesicular Monoamine Transporter (VMAT)

Clinical Mechanism:

Under monoamine oxidase (MAO) inhibition, ingested dietary tyramine escapes intestinal deamination, enters systemic circulation, and displaces massive catecholamine stores, triggering acute fatal hypertensive crises, intracranial hemorrhage, and cardiac arrest.

Patient Actionable Rule:Strict dietary tyramine restriction is required starting on the first day of MAOI therapy and continuing for 14 days after discontinuation to allow MAO enzyme regeneration.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

1 Warning Classes

HIGH RISK

NSAIDs (Ibuprofen, Naproxen) & Non-Cardioprotective Analgesics

openFDA SPL Section 7 (Drug Interactions)

Mechanism: Inhibition of renal vasodilatory prostaglandins (PGI2, PGE2) causes afferent arteriolar vasoconstriction, blunts blood pressure control, and increases risk of acute kidney injury (AKI).

Clinical Consequence: Loss of blood pressure reduction, fluid retention, or acute renal hemodynamic compromise.

Physician Precaution: Consult your physician before taking OTC pain relievers. Acetaminophen may be preferred for occasional pain depending on liver status.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

0 Monitored

No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

2 Protocols

MEALMealtime Administration

The delayed-release tablets (Lialda) are usually taken with food once a day by adults and children.

Rationale: Food enhances bioavailability, prevents gastric mucosal irritation, or stabilizes peak-to-trough pharmacokinetic variations.

EMPTY_STOMACHEmpty Stomach Protocol

The delayed-release tablets (Asacol HD) are usually taken on an empty stomach three times a day (1 hour before or 2 hours after meals) by adults.

Rationale: Food constituents interfere with gastrointestinal absorption or gastric emptying.

Frequently Researched Drug-Substance Combinations

Explore pairwise interaction dossiers and laboratory safety analyses

HIGH→

Mesalamine and Aspirin / NSAIDs

Pairwise Clinical Analysis & Safety Rating

Multi-Substance Interactive Radar

Taking Mesalamine alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Mesalamine→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers