Indinavir
Comprehensive clinical interaction and dietary monograph for Indinavir (Indinavir).
Kitchen Food, Drink & Dietary Conflicts
Biochemical interactions with common foods, beverages & cooking ingredientsDrink at least 48 ounces (1.5 liters), which is approximately six 8-ounce (240-milliliter) glasses, of water or other liquids every 24 hours. Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.
Grapefruit / Pomelo (Citrus paradisi / Citrus maxima)
Destroys enterocyte CYP3A4 enzymes, collapsing first-pass drug metabolism and causing up to 12-fold spikes in bioavailability for oral CYP3A4 substrates (statins, calcium channel blockers, immunosuppressants, PDE5 inhibitors).
Green Tea, Black Tea & Matcha (Tannins & OATP Inhibitors)
Tannins form insoluble macromolecular iron-tannate precipitates, dropping non-heme iron absorption by up to 80%. Catechins additionally inhibit intestinal OATP uptake transporters, drastically reducing bioavailability of beta-blockers (atenolol) and allergy medications (fexofenadine).
Coffee & High-Caffeine Beverages (Espresso, Energy Drinks)
Ciprofloxacin, fluvoxamine, and oral contraceptives inhibit CYP1A2, reducing caffeine clearance by 30-80% and precipitating palpitations, panic, and severe tremors. Caffeine also accelerates gastric motility, impairing bisphosphonate and thyroid absorption.
Dairy Milk, Yogurt & Calcium-Enriched Foods
Divalent calcium binds fluoroquinolone (ciprofloxacin) and tetracycline (doxycycline) antibiotics into unabsorbable ring complexes, reducing systemic antibacterial coverage by up to 90% and causing therapy failure.
Fresh Orange Juice & Apple Juice (OATP Influx Blockers)
Unlike CYP3A4 inhibitors that increase drug levels, fruit juice bioflavonoids block the enterocyte OATP influx pumps, plummeting absorption of oral fexofenadine (Allegra), ciprofloxacin, and atenolol by 30-70%.
Prescription & OTC Drug Interactions (DDI)
Documented pharmacological conflicts & contraindicated co-prescriptionsDietary Supplements, Herbs & Minerals (DNI)
Interactions with over-the-counter vitamins, minerals, and herbal preparationsChronotherapy & Meal Administration Protocols
Optimal absorption, meal-timing rules & GI tolerability protocolsTake indinavir on an empty stomach, 1 hour before meals or 2 hours after meals, with water, skim or nonfat milk, juice, coffee, or tea.
Rationale: Food constituents interfere with gastrointestinal absorption or gastric emptying.
Frequently Researched Drug-Substance Combinations
Explore pairwise interaction dossiers and laboratory safety analysesTaking Indinavir alongside daily coffee, supplements, or other medications?
Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.
Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.