Cannabidiol
Comprehensive clinical interaction and dietary monograph for Cannabidiol (Cannabidiol).
Kitchen Food, Drink & Dietary Conflicts
Biochemical interactions with common foods, beverages & cooking ingredientsTalk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.
Grapefruit / Pomelo (Citrus paradisi / Citrus maxima)
Destroys enterocyte CYP3A4 enzymes, collapsing first-pass drug metabolism and causing up to 12-fold spikes in bioavailability for oral CYP3A4 substrates (statins, calcium channel blockers, immunosuppressants, PDE5 inhibitors).
Coffee & High-Caffeine Beverages (Espresso, Energy Drinks)
Ciprofloxacin, fluvoxamine, and oral contraceptives inhibit CYP1A2, reducing caffeine clearance by 30-80% and precipitating palpitations, panic, and severe tremors. Caffeine also accelerates gastric motility, impairing bisphosphonate and thyroid absorption.
Fresh Orange Juice & Apple Juice (OATP Influx Blockers)
Unlike CYP3A4 inhibitors that increase drug levels, fruit juice bioflavonoids block the enterocyte OATP influx pumps, plummeting absorption of oral fexofenadine (Allegra), ciprofloxacin, and atenolol by 30-70%.
Alcoholic Beverages (Beer, Wine, Spirits)
Multiplies respiratory depression and profound sedation with opioids and sedatives; blocks hepatic lactate uptake with metformin (lactic acidosis); triggers acute disulfiram-like vomiting and tachycardia with metronidazole; and accelerates dose-dumping in extended-release capsules.
Prescription & OTC Drug Interactions (DDI)
Documented pharmacological conflicts & contraindicated co-prescriptionsDietary Supplements, Herbs & Minerals (DNI)
Interactions with over-the-counter vitamins, minerals, and herbal preparationsSt. John's Wort (Hypericum perforatum)
Hyperforin potently activates the Pregnane X Receptor (PXR), inducing hepatic CYP enzymes and intestinal P-gp pumps. This accelerates medication clearance and precipitates therapeutic failure.
Chronotherapy & Meal Administration Protocols
Optimal absorption, meal-timing rules & GI tolerability protocolsFrequently Researched Drug-Substance Combinations
Explore pairwise interaction dossiers and laboratory safety analysesCannabidiol and Grapefruit
Pairwise Clinical Analysis & Safety RatingCannabidiol and Grapefruit-juice
Pairwise Clinical Analysis & Safety RatingCannabidiol and Grapefruit / Pomelo
Pairwise Clinical Analysis & Safety RatingCannabidiol and Alcoholic Beverages
Pairwise Clinical Analysis & Safety RatingTaking Cannabidiol alongside daily coffee, supplements, or other medications?
Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.
Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.