Prescription Clinical MonographPrescription Therapeutic Agent

Verified Evidence Sources: openFDA & NLM MedlinePlus

Aspirin

Comprehensive clinical interaction and dietary monograph for Aspirin (Aspirin).

Generic Active Chemical: Aspirin

Brand Formulations:Acuprin¶Anacin Aspirin Regimen¶Ascriptin¶Aspergum¶Aspidrox¶Aspir-Mox¶Aspirtab¶Aspir-trin¶Bayer AspirinBufferinBuffex¶Easprin¶EcotrinEmpirin¶Entaprin¶Entercote¶Fasprin¶Genacote¶Gennin-FC¶Genprin¶Halfprin¶Magnaprin¶Miniprin¶Minitabs¶Ridiprin¶Sloprin¶Uni-Buff¶Uni-Tren¶Valomag¶Zorprin¶Alka-Seltzer (as various combination products containing Aspirin)Alor (containing Aspirin, Hydrocodone)¶Anacin (containing Aspirin, Caffeine)Anacin Advanced Headache Formula (containing Acetaminophen, Aspirin, Caffeine)Aspircaf (containing Aspirin, Caffeine)¶Axotal (containing Aspirin, Butalbital)¶Azdone (containing Aspirin, Hydrocodone)¶Bayer Aspirin Plus Calcium (containing Aspirin, Calcium Carbonate)Bayer Aspirin PM (containing Aspirin, Diphenhydramine)Bayer Back and Body Pain (containing Aspirin, Caffeine)BC Powder (as various combination products containing Aspirin and Caffeine)¶Damason-P (containing Aspirin, Hydrocodone)Emagrin (containing Aspirin, Caffeine, Salicylamide)¶Endodan (containing Aspirin, Oxycodone)¶Equagesic (containing Aspirin, Meprobamate)¶Excedrin (containing Acetaminophen, Aspirin, Caffeine)Excedrin Back & Body (containing Acetaminophen, Aspirin)Goody's Powder (as various combination products containing Aspirin)Levacet (containing Acetaminophen, Aspirin, Caffeine, Salicylamide)¶Lortab ASA (containing Aspirin, Hydrocodone)¶Micrainin (containing Aspirin, Meprobamate)¶Momentum (containing Aspirin, Phenyltoloxamine)¶Norgesic (containing Aspirin, Caffeine, Orphenadrine)¶Orphengesic (containing Aspirin, Caffeine, Orphenadrine)Panasal (containing Aspirin, Hydrocodone)¶Percodan (containing Aspirin, Oxycodone)Robaxisal (containing Aspirin, Methocarbamol)¶Roxiprin (containing Aspirin, Oxycodone)¶Saleto (containing Acetaminophen, Aspirin, Caffeine, Salicylamide)¶Soma Compound (containing Aspirin, Carisoprodol)Soma Compound with Codeine (containing Aspirin, Carisoprodol, Codeine)Supac (containing Acetaminophen, Aspirin, Caffeine)¶Synalgos-DC (containing Aspirin, Caffeine, Dihydrocodeine)¶Talwin Compound (containing Aspirin, Pentazocine)¶Vanquish (containing Acetaminophen, Aspirin, Caffeine)¶

Quick Jump:Kitchen Foods (2)Drug Red Flags (1)Supplements & Herbs (0)Administration Timing (2)Pairwise Combos (4)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

2 Flagged Foods

HIGH

Coffee & High-Caffeine Beverages (Espresso, Energy Drinks)

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:1,3,7-Trimethylxanthine (Caffeine)

Biological Target:Cytochrome P450 1A2 (CYP1A2) & Adenosine A1/A2A Receptors

Clinical Mechanism:

Ciprofloxacin, fluvoxamine, and oral contraceptives inhibit CYP1A2, reducing caffeine clearance by 30-80% and precipitating palpitations, panic, and severe tremors. Caffeine also accelerates gastric motility, impairing bisphosphonate and thyroid absorption.

Patient Actionable Rule:Take thyroid hormones and bisphosphonates with pure plain water only. Moderate or avoid concentrated caffeine during ciprofloxacin therapy.

HIGH

Alcoholic Beverages (Beer, Wine, Spirits)

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:Ethanol

Biological Target:GABA-A Receptors, Hepatic CYP2E1 & Gluconeogenesis

Clinical Mechanism:

Multiplies respiratory depression and profound sedation with opioids and sedatives; blocks hepatic lactate uptake with metformin (lactic acidosis); triggers acute disulfiram-like vomiting and tachycardia with metronidazole; and accelerates dose-dumping in extended-release capsules.

Patient Actionable Rule:Completely abstain from alcohol while taking metronidazole, cephalosporins, prescription sedatives, or empty-stomach metformin.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

1 Warning Classes

HIGH RISK

NSAIDs (Ibuprofen, Naproxen) & Non-Cardioprotective Analgesics

openFDA SPL Section 7 (Drug Interactions)

Mechanism: Inhibition of renal vasodilatory prostaglandins (PGI2, PGE2) causes afferent arteriolar vasoconstriction, blunts blood pressure control, and increases risk of acute kidney injury (AKI).

Clinical Consequence: Loss of blood pressure reduction, fluid retention, or acute renal hemodynamic compromise.

Physician Precaution: Consult your physician before taking OTC pain relievers. Acetaminophen may be preferred for occasional pain depending on liver status.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

0 Monitored

No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

2 Protocols

MEALAdministration Rule

Swallow the extended-release tablets whole with a full glass of water.

Rationale: Promotes optimal mucosal absorption and consistent therapeutic plasma levels.

MEALAdministration Rule

Drink a full glass of water immediately after taking these tablets.

Rationale: Promotes optimal mucosal absorption and consistent therapeutic plasma levels.

Frequently Researched Drug-Substance Combinations

Explore pairwise interaction dossiers and laboratory safety analyses

CRITICAL→

Multi-Substance Interactive Radar

Taking Aspirin alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Aspirin→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers