Amiodarone
Comprehensive clinical interaction and dietary monograph for Amiodarone (Amiodarone).
Kitchen Food, Drink & Dietary Conflicts
Biochemical interactions with common foods, beverages & cooking ingredientsDo not drink grapefruit juice while you are taking this medication.
Grapefruit / Pomelo (Citrus paradisi / Citrus maxima)
Destroys enterocyte CYP3A4 enzymes, collapsing first-pass drug metabolism and causing up to 12-fold spikes in bioavailability for oral CYP3A4 substrates (statins, calcium channel blockers, immunosuppressants, PDE5 inhibitors).
Natural Black Licorice & Licorice Root Extracts
Inhibits cortisol breakdown into cortisone in the kidney. Cortisol saturates mineralocorticoid receptors, causing massive renal sodium retention, severe potassium wasting, edema, and dangerous spikes in blood pressure that neutralize antihypertensives.
Fresh Orange Juice & Apple Juice (OATP Influx Blockers)
Unlike CYP3A4 inhibitors that increase drug levels, fruit juice bioflavonoids block the enterocyte OATP influx pumps, plummeting absorption of oral fexofenadine (Allegra), ciprofloxacin, and atenolol by 30-70%.
Prescription & OTC Drug Interactions (DDI)
Documented pharmacological conflicts & contraindicated co-prescriptionsDietary Supplements, Herbs & Minerals (DNI)
Interactions with over-the-counter vitamins, minerals, and herbal preparationsChronotherapy & Meal Administration Protocols
Optimal absorption, meal-timing rules & GI tolerability protocolsFrequently Researched Drug-Substance Combinations
Explore pairwise interaction dossiers and laboratory safety analysesTaking Amiodarone alongside daily coffee, supplements, or other medications?
Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.
Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.