Alfuzosin
Alfuzosin selectively blocks postsynaptic alpha-1 adrenoreceptors in the prostate, bladder base, and prostatic capsule, relaxing smooth muscle without significant peripheral vascular syncope when taken properly with food.
Kitchen Food, Drink & Dietary Conflicts
Biochemical interactions with common foods, beverages & cooking ingredientsTalk to your doctor about eating grapefruit or drinking grapefruit juice while taking this medication.
Grapefruit / Pomelo (Citrus paradisi / Citrus maxima)
Destroys enterocyte CYP3A4 enzymes, collapsing first-pass drug metabolism and causing up to 12-fold spikes in bioavailability for oral CYP3A4 substrates (statins, calcium channel blockers, immunosuppressants, PDE5 inhibitors).
Fresh Orange Juice & Apple Juice (OATP Influx Blockers)
Unlike CYP3A4 inhibitors that increase drug levels, fruit juice bioflavonoids block the enterocyte OATP influx pumps, plummeting absorption of oral fexofenadine (Allegra), ciprofloxacin, and atenolol by 30-70%.
Prescription & OTC Drug Interactions (DDI)
Documented pharmacological conflicts & contraindicated co-prescriptionsPotent CYP3A4 Inhibitors (Ketoconazole, Itraconazole, Ritonavir)
Mechanism: Alfuzosin is extensively metabolized by hepatic CYP3A4. Strong inhibitors cause dramatic elevations in plasma drug levels and area under the curve (AUC).
Phosphodiesterase-5 (PDE5) Inhibitors (Sildenafil, Tadalafil)
Mechanism: Additive peripheral vasodilatory synergy across alpha-adrenergic blockade and cGMP accumulation pathways.
Dietary Supplements, Herbs & Minerals (DNI)
Interactions with over-the-counter vitamins, minerals, and herbal preparationsSt. John's Wort (Hypericum perforatum)
Hyperforin potently activates the Pregnane X Receptor (PXR), inducing hepatic CYP enzymes and intestinal P-gp pumps. This accelerates medication clearance and precipitates therapeutic failure.
Chronotherapy & Meal Administration Protocols
Optimal absorption, meal-timing rules & GI tolerability protocolsDo not take alfuzosin on an empty stomach.
Rationale: Food constituents interfere with gastrointestinal absorption or gastric emptying.
Frequently Researched Drug-Substance Combinations
Explore pairwise interaction dossiers and laboratory safety analysesTaking Alfuzosin alongside daily coffee, supplements, or other medications?
Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.
Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.